Protein Name:
Neurocalcin homolog
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UniprotKB/SwissProt ID: P42325 (P42325)
Gene Name:
Nca
Organism: Drosophila melanogaster (Fruit fly)
Function: Calcium-binding protein that is essential for promoting night-time sleep and inhibiting nocturnal hyperactivity (PubMed:30865587, PubMed:7989365). During the night-time it promotes sleep by limiting synaptic output from arousal- and wake-promoting neurons within the C01- and A05- domains that include the mushroom body, and the antennal mechanosensory and motor center (PubMed:30865587). Regulated by the circadian clock network and light-sensing circuits that include the CRY photoreceptor; it is likely that both of these internal and external cues are required to define the temporal window (the night-time) during which this protein functions (PubMed:30865587). Inhibits the phosphorylation of rhodopsin in a calcium-dependent manner (PubMed:8626592)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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