UniprotKB/SwissProt ID: P42081 (P42081)
Gene Name:
CD86
Organism: Homo sapiens (Human)
Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4 (PubMed:12196291). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (PubMed:7527824). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced. Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity) Interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation (Microbial infection) Acts as a receptor for adenovirus subgroup B
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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