Protein Name:
Vasoactive intestinal polypeptide receptor 2
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UniprotKB/SwissProt ID: P41588 (P41588)
Gene Name:
Vipr2
Organism: Mus musculus (Mouse)
Function: G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP). Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the order of ligand affinity of VIP = PACAP38 > PACAP27. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (By similarity). May be coupled to phospholipase C
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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