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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: DNA topoisomerase 2-alpha

UniprotKB/SwissProt ID: P41516 (P41516)

Gene Name: Top2a

Organism: Rattus norvegicus (Rat)

Function: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (By similarity). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus. Nucleus, nucleolus

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR050634 DNA_Topoisomerase_II
IPR012542 DTHCT
IPR036890 HATPase_C_sf
IPR020568 Ribosomal_Su5_D2-typ_SF
IPR014721 Ribsml_uS5_D2-typ_fold_subgr
IPR001241 Topo_IIA
IPR013760 Topo_IIA-like_dom_sf
IPR013758 Topo_IIA_A/C_ab
IPR013757 Topo_IIA_A_a_sf
IPR013759 Topo_IIA_B_C
IPR013506 Topo_IIA_bsu_dom2
IPR002205 Topo_IIA_dom_A
IPR001154 TopoII_euk
IPR018522 TopoIIA_CS
IPR031660 TOPRIM_C
IPR006171 TOPRIM_dom
IPR034157 TOPRIM_TopoII

The S-nitrosylation sites of P41516

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 168 GGRNGYGAKL C NIFSTKFTVE