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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Isoleucine--tRNA ligase, cytoplasmic
UniprotKB/SwissProt ID: P41252 (P41252)

Gene Name: IARS1

Organism: Homo sapiens (Human)

Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR033709 Anticodon_Ile_ABEc
IPR002301 Ile-tRNA-ligase
IPR023586 Ile-tRNA-ligase_type2
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR057033 Ubiquitin_IARS1
IPR009008 Val/Leu/Ile-tRNA-synth_edit
The S-nitrosylation sites of P41252
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1001 INRIQKLRKK C NLVPTDEITV   
2 120 KMGITEYNNQ C RAIVMRYSAE   
3 185 GVKVMPFSTA C NTPLSNFESH   
4 27 KILEFWTEFN C FQECLKQSKH   
5 336 PYFGAEDYRV C MDFNIIRKDS   
6 350 NIIRKDSLPV C PVDASGCFTT   
7 357 LPVCPVDASG C FTTEVTDFAG   
8 433 VDQLLRNNDL C YWVPELVREK   
9 87 FHVDRRFGWD C HGLPVEYEID