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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glycine--tRNA ligase
UniprotKB/SwissProt ID: P41250 (P41250)

Gene Name: GARS1

Organism: Homo sapiens (Human)

Function: Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:17544401, PubMed:24898252, PubMed:28675565). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (PubMed:19710017)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Cell projection, axon. Secreted. Secreted, extracellular exosome. Mitochondrion. Cytoplasm. Cytoplasm. Cell projection, axon

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002314 aa-tRNA-synt_IIb
IPR006195 aa-tRNA-synth_II
IPR045864 aa-tRNA-synth_II/BPL/LPL
IPR004154 Anticodon-bd
IPR036621 Anticodon-bd_dom_sf
IPR027031 Gly-tRNA_synthase/POLG2
IPR033731 GlyRS-like_core
IPR002315 tRNA-synt_gly
IPR009068 uS15_NS1_RNA-bd_sf
IPR000738 WHEP-TRS_dom
The S-nitrosylation sites of P41250
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 180 IQEEQILEID C TMLTPEPVLK  CCCCCCCCCH H HHHHHHHHCC 
2 461 TSYGWIEIVG C ADRSCYDLSC  CCCCCCCCCH H HHHHHHHHCC 
3 466 IEIVGCADRS C YDLSCHARAT  CCCCCCCCCH H HHHHHHHHCC  19483679
4 471 CADRSCYDLS C HARATKVPLV  CCCCCCCCCH H HHHHHHHHCC  19483679
5 616 SFPAVVAPFK C SVLPLSQNQE  CCCCCCCCCH H HHHHHHHHCC  37478858