Protein Name:
Phospholipid-transporting ATPase ABCA1
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UniprotKB/SwissProt ID: P41233 (P41233)
Gene Name:
Abca1
Organism: Mus musculus (Mouse)
Function: Catalyzes the translocation of specific phospholipids from the cytoplasmic to the extracellular/lumenal leaflet of membrane coupled to the hydrolysis of ATP. Thereby, participates in phospholipid transfer to apolipoproteins to form nascent high density lipoproteins/HDLs. Transports preferentially phosphatidylcholine over phosphatidylserine. May play a similar role in the efflux of intracellular cholesterol to apolipoproteins and the formation of nascent high density lipoproteins/HDLs. Translocates phospholipids from the outer face of the plasma membrane and forces it through its gateway and annulus into an elongated hydrophobic tunnel in its extracellular domain
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Endosome
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Graphical Visualization of S-nitrosylation Sites:
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