UniprotKB/SwissProt ID: P41220 (P41220)
Gene Name:
RGS2
Organism: Homo sapiens (Human)
Function: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm. Nucleus, nucleolus. Cell membrane. Cytoplasm. Nucleus, nucleolus. Cell membrane. Cytoplasm. Nucleus, nucleolus. Cell membrane. Mitochondrion
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