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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Malate dehydrogenase, cytoplasmic
UniprotKB/SwissProt ID: P40925 (P40925)

Gene Name: MDH1

Organism: Homo sapiens (Human)

Function: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001557 L-lactate/malate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR011274 Malate_DH_NAD-dep_euk
IPR010945 Malate_DH_type2
IPR036291 NAD(P)-bd_dom_sf
The S-nitrosylation sites of P40925
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 137 IVVGNPANTN C LTASKSAPSI  CCCCEEEEEE C CHHHHHHHHH  3.17% 18335467
37478858
2 154 APSIPKENFS C LTRLDHNRAK  CCCCEEEEEE C CHHHHHHHHH  3.83% 24105792
3 251 SSAMSAAKAI C DHVRDIWFGT  CCCCEEEEEE C CHHHHHHHHH  3.37%