UniprotKB/SwissProt ID: P40792 (P40792)
Gene Name:
Rac1
Organism: Drosophila melanogaster (Fruit fly)
Function: During various developmental processes, regulates changes in cell morphology in response to extracellular signals (PubMed:10323867, PubMed:24855950, PubMed:7958857). During oogenesis, mediates signaling from the tyrosine kinase (RTK) chemoattractant receptors (Egfr and Pvr) to the guidance pathway that control the directional persistent collective migration of the border cell (BC) cluster through the nurse cells to the oocyte. Once activating by Pvr and Egfr, promotes the formation of forward-directed actin protrusions which stabilize the DE-cadherin (shg)-mediated adhesions. In turn, DE-mediated adhesion between the leader border cells and nurse cells further promotes Rac1 signaling creating a positive feedback loop that amplifies the output of RTK activity and leads to higher Rac activity at the front, thus promoting polarization of the border cell cluster and directionally persistent migration (PubMed:24855950). Involved in axon outgrowth and myoblast fusion (PubMed:7958857). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867). Involved in integrin alpha-PS3/beta-nu-mediated phagocytosis of Gram-positive S.aureus by hemocytes (PubMed:22547074)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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