Protein Name:
von Hippel-Lindau disease tumor suppressor
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UniprotKB/SwissProt ID: P40338 (P40338)
Gene Name:
Vhl
Organism: Mus musculus (Mouse)
Function: Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Endoplasmic reticulum. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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