Protein Name:
CD82 antigen
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UniprotKB/SwissProt ID: P40237 (P40237)
Gene Name:
Cd82
Organism: Mus musculus (Mouse)
Function: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity). Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (PubMed:31408613). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (PubMed:35754722). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (PubMed:21149584). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (PubMed:34530889)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasmic vesicle, phagosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P40237
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
174 |
LMGFTKTTYP C SCEKIKEEDN |
CCCCHHHHHH H HHHHHHHHHH |
5.24% |
22588120
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| 2 |
176 |
GFTKTTYPCS C EKIKEEDNQL |
CCCCHHHHHH H HHHHHHHHHH |
8.65% |
22588120
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