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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit zeta
UniprotKB/SwissProt ID: P40227 (P40227)

Gene Name: CCT6A

Organism: Homo sapiens (Human)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012722 Chap_CCT_zeta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/GroEL/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR053374 TCP-1_chaperonin
The S-nitrosylation sites of P40227
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 233 KRVEDAYILT C NVSLEYEKTE  CCCCCCCCHH H HHHHHHHHHH  4.19%
2 282 KKIIELKRKV C GDSDKGFVVI  CCCCCCCCHH H HHHHHHHHHH  5.86%
3 343 LNSFDDLSPD C LGHAGLVYEY  CCCCCCCCHH H HHHHHHHHHH  5.79%
4 406 RAVKNAIDDG C VVPGAGAVEV  CCCCCCCCHH H HHHHHHHHHH  3.43% 22178444
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