UniprotKB/SwissProt ID: P39968 (P39968)
Gene Name:
VAC8
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole (cvt) (PubMed:9490720). Involved in the formation of nucleus-vacuole junctions (NVJs) during piecemeal microautophagy of the nucleus (PMN) (PubMed:10888680, PubMed:12529432, PubMed:16912077). NVJs are interorganelle interfaces mediated by NVJ1 in the nuclear envelope and VAC8 on the vacuole membrane (PubMed:10888680, PubMed:12529432, PubMed:16912077). Together, NVJ1 and VAC8 form Velcro-like patches through which teardrop-like portions of the nucleus are pinched off into the vacuolar lumen and degraded by the PMN process (PubMed:10888680, PubMed:12529432, PubMed:16912077)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Vacuole membrane
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