UniprotKB/SwissProt ID: P39905 (P39905)
Gene Name:
GDNF
Organism: Homo sapiens (Human)
Function: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:8493557). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (PubMed:10829012, PubMed:25242331, PubMed:31535977). Involved in the development of the neural crest (PubMed:15242795)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted
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