UniprotKB/SwissProt ID: P39087 (P39087)
Gene Name:
Grik2
Organism: Mus musculus (Mouse)
Function: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:17620617, PubMed:19217376, PubMed:20007474, PubMed:31474366, PubMed:7681676). Modulates cell surface expression of NETO2 (PubMed:19217376). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (PubMed:17620617) Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (PubMed:31474366) Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Postsynaptic cell membrane
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