UniprotKB/SwissProt ID: P39061 (P39061)
Gene Name:
Col18a1
Organism: Mus musculus (Mouse)
Function: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non-endothelial cells; the function requires homotrimerization and implicates MAPK signaling Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (PubMed:9008168). Inhibits VEGFA isoform VEGF165-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA-mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2 (PubMed:12029087). Modulates endothelial cell migration in an integrin-dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (PubMed:11158588). May negatively regulate the activity of homotrimeric non-collagenous domain 1 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, extracellular matrix, basement membrane. Secreted, extracellular space, extracellular matrix, basement membrane. Secreted. Secreted. Secreted, extracellular space, extracellular matrix, basement membrane
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