UniprotKB/SwissProt ID: P38922 (P38922)
Gene Name:
HRB1
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: Binds to intron-containing transcripts and is involved in quality control for the export of spliced mRNAs from the nucleus (PubMed:14676199, PubMed:14769921, PubMed:24452287). Binds to pre-mRNAs until splicing is completed or until faulty mRNAs are degraded. On correctly spliced mRNAs, GBP2 and HRB1 recruit MEX67 to allow nuclear export. On faulty mRNAs, GBP2 and HRB1 associate with the TRAMP complex that guides those pre-mRNAs to the exosome for degradation (PubMed:24452287)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Nucleus. Cytoplasm, P-body. Cytoplasm, Stress granule
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