Protein Name:
Guanine nucleotide-binding protein G(olf) subunit alpha
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UniprotKB/SwissProt ID: P38406 (P38406)
Gene Name:
Gnal
Organism: Rattus norvegicus (Rat)
Function: Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (PubMed:2255909, PubMed:2499043). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (PubMed:2255909, PubMed:2499043). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (PubMed:2255909)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P38406
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
346 |
STATGDGKHY C YPHFTCAVDT |
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| 2 |
352 |
GKHYCYPHFT C AVDTENIRRV |
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