UniprotKB/SwissProt ID: P38273 (P38273)
Gene Name:
CCZ1
Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Function: In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The MON1-CCZ1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking (PubMed:10407278, PubMed:11069774, PubMed:11590240, PubMed:12208507, PubMed:12364329, PubMed:14662743, PubMed:15184059, PubMed:15721293, PubMed:32391792, PubMed:37463208). The MON1-CCZ1 complex is recruited to membranes enriched in charged lipids, particularly phosphatidylinositol 3-phosphate (PtdIns3P), by GTP-associated small GTPase RAB5 homologs (YPT10, YPT52, YPT53 and VPS21) (PubMed:32391792). The MON1-CCZ1 complex recruits GDP-associated small GTPase YPT7 to membranes and acts as a guanine nucleotide-exchange factor (GEF), promoting nucleotide exchange on YPT7 and triggering endosomal maturation by recruiting downstream effectors such as components of the HOPS tethering complex (PubMed:20797862, PubMed:32391792)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endosome, multivesicular body membrane. Prevacuolar compartment membrane. Vacuole membrane. Vesicle
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