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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Electron transfer flavoprotein subunit beta

UniprotKB/SwissProt ID: P38117 (P38117)

Gene Name: ETFB

Organism: Homo sapiens (Human)

Function: Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase (PubMed:15159392, PubMed:15975918, PubMed:25416781). It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (Probable). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism (PubMed:12815589, PubMed:7912128). ETFB binds an AMP molecule that probably has a purely structural role (PubMed:15159392, PubMed:15975918, PubMed:8962055)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR000049 ET-Flavoprotein_bsu_CS
IPR014730 ETF_a/b_N
IPR012255 ETF_b
IPR033948 ETF_beta_N
IPR014729 Rossmann-like_a/b/a_fold

The S-nitrosylation sites of P38117

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 42 DGVKHSMNPF C EIAVEEAVRL   
2 66 KLVKEVIAVS C GPAQCQETIR   
3 71 VIAVSCGPAQ C QETIRTALAM