Protein Name:
Hydroxymethylglutaryl-CoA lyase, mitochondrial
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UniprotKB/SwissProt ID: P38060 (P38060)
Gene Name:
Hmgcl
Organism: Mus musculus (Mouse)
Function: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P38060
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
141 |
SELFTRKNAN C SIEESFQRFA |
CCHHHHHCHH H HHCHHHEEEE |
3.94% |
22178444
21278135
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| 2 |
170 |
ASISVRGYVS C ALGCPYEGKV |
CCHHHHHCHH H HHCHHHEEEE |
2.3% |
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| 3 |
307 |
QKLLEAGDFI C QALNRKTSSK |
CCHHHHHCHH H HHCHHHEEEE |
1.63% |
22178444
21278135
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