Protein Name:
Squalene synthase
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UniprotKB/SwissProt ID: P37268 (P37268)
Gene Name:
FDFT1
Organism: Homo sapiens (Human)
Function: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P37268
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
147 |
EKYQTVIADI C RRMGIGMAEF |
CCCCCCCCCH H HHHHHHHHEE |
2.02% |
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| 2 |
374 |
STIRTQNLPN C QLISRSHYSP |
CCCCCCCCCH H HHHHHHHHEE |
3.08% |
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| 3 |
6 |
-----MEFVK C LGHPEEFYNL |
CCCCCCCCCH H HHHHHHHHEE |
4.65% |
19483679
37478858
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