Protein Name:
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial
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UniprotKB/SwissProt ID: P36957 (P36957)
Gene Name:
DLST
Organism: Homo sapiens (Human)
Function: Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P36957
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
GDTVAEDEVV C EIETDKTSVQ |
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