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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Low-density lipoprotein receptor

UniprotKB/SwissProt ID: P35952 (P35952)

Gene Name: Ldlr

Organism: Rattus norvegicus (Rat)

Function: Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR051221 LDLR-related
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
IPR049883 NOTCH1_EGF-like

The S-nitrosylation sites of P35952

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 75 SVTCRSGEFS C GGRVSRCIPD