Protein Name:
Tyrosine-protein phosphatase non-receptor type 1
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UniprotKB/SwissProt ID: P35821 (P35821)
Gene Name:
Ptpn1
Organism: Mus musculus (Mouse)
Function: Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35821
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
215 |
SLEHGPIVVH C SAGIGRSGTF |
CCCHHHHHHH H HHCCHHHHHH |
1.69% |
20925432
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| 2 |
92 |
ILTQGPLPNT C GHFWEMVWEQ |
CCCHHHHHHH H HHCCHHHHHH |
5.18% |
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