Protein Name:
Protein phosphatase 1A
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UniprotKB/SwissProt ID: P35813 (P35813)
Gene Name:
PPM1A
Organism: Homo sapiens (Human)
Function: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm, cytosol. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35813
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
144 |
ISPQHTYFIN C GDSRGLLCRN |
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| 2 |
314 |
KEAELDKYLE C RVEEIIKKQG |
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