Protein Name:
Neuronal membrane glycoprotein M6-a
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UniprotKB/SwissProt ID: P35802 (P35802)
Gene Name:
Gpm6a
Organism: Mus musculus (Mouse)
Function: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. Conflictingly, PubMed:22162747 reports that induced cellular protrusions are simple membrane-wrapped tubules without actin or tubulin-based cytoskeletons and with Gpm6a gliding along membrane edges indicative for a function in actin-independent membrane deformation. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, axon. Cell projection, growth cone. Cell projection, dendritic spine. Cell projection, filopodium. Cell projection, neuron projection
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35802
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
192 |
IVTIGEEKKI C TASENFLRMC |
CCCCCCCCCC C CCHHHHHHHH |
3.41% |
22588120
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