Protein Name:
Cystathionine beta-synthase
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UniprotKB/SwissProt ID: P35520 (P35520)
Gene Name:
CBS
Organism: Homo sapiens (Human)
Function: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine (PubMed:20506325, PubMed:23974653, PubMed:23981774). Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35520
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
103 |
NKIGKKFGLK C ELLAKCEFFN |
CCCCCCCCCC C CCCCCCCCCC |
5.53% |
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| 2 |
109 |
FGLKCELLAK C EFFNAGGSVK |
CCCCCCCCCC C CCCCCCCCCC |
4.6% |
24105792
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| 3 |
15 |
TPQAEVGPTG C PHRSGPHSAK |
CCCCCCCCCC C CCCCCCCCCC |
2.56% |
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| 4 |
346 |
RMLIAQEGLL C GGSAGSTVAV |
CCCCCCCCCC C CCCCCCCCCC |
7.54% |
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| 5 |
370 |
AAQELQEGQR C VVILPDSVRN |
CCCCCCCCCC C CCCCCCCCCC |
1.89% |
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