\
logo
  Home | Contact us | Browse | Quick Search by UniProtKB ID, Keyword, PDBID

Menu:

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Read more...


Protein Name: Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

UniprotKB/SwissProt ID: P35486 (P35486)

Gene Name: Pdha1

Organism: Mus musculus (Mouse)

Function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion matrix

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001017 DH_E1
IPR050642 PDH_E1_Alpha_Subunit
IPR017597 Pyrv_DH_E1_asu_subgrp-y
IPR029061 THDP-binding

The S-nitrosylation sites of P35486

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 100 FCHLCDGQEA C CVGLEAGINP  CHHHHHHHHH H HHCCCCCCHH  1.58% 24895380
2 101 CHLCDGQEAC C VGLEAGINPT  CHHHHHHHHH H HHCCCCCCHH  3.33% 24895380
3 181 VPLGAGIALA C KYNGKDEVCL  CHHHHHHHHH H HHCCCCCCHH  5.1% 21278135
4 218 YNMAALWKLP C IFICENNRYG  CHHHHHHHHH H HHCCCCCCHH  6.02% 22588120
5 222 ALWKLPCIFI C ENNRYGMGTS  CHHHHHHHHH H HHCCCCCCHH  2.97% 22588120
6 261 GLRVDGMDIL C VREATKFAAA  CHHHHHHHHH H HHCCCCCCHH  2.5% 24895380
21278135
7 273 REATKFAAAY C RSGKGPILME  CHHHHHHHHH H HHCCCCCCHH  2.09% 21278135
8 41 ANDATFEIKK C DLHRLEEGPP  CHHHHHHHHH H HHCCCCCCHH  5.98% 21278135
9 91 LYKQKIIRGF C HLCDGQEACC  CHHHHHHHHH H HHCCCCCCHH  2.39% 24895380
10 94 QKIIRGFCHL C DGQEACCVGL  CHHHHHHHHH H HHCCCCCCHH  2.16% 24895380