UniprotKB/SwissProt ID: P35413 (P35413)
Gene Name:
Gpr3
Organism: Mus musculus (Mouse)
Function: Constitutively active G-protein coupled receptor that maintains high 3'-5'-cyclic adenosine monophosphate (cAMP) levels that a plays a role in serveral processes including meiotic arrest in oocytes or neuronal development via activation of numerous intracellular signaling pathways (PubMed:15956199, PubMed:19259266). Acts as an essential activator of thermogenic adipocytes and drives thermogenesis via its intrinsic G(s)-coupling activity without the requirement of a ligand (PubMed:26455425, PubMed:34048700). Has a potential role in modulating a number of brain functions, including behavioral responses to stress, amyloid-beta peptide generation in neurons. Stimulates neurite outgrowth in cerebellar granular neurons modulated via PKA, ERK, and most strongly PI3K-mediated signaling pathways (PubMed:34871769)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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