UniprotKB/SwissProt ID: P35363 (P35363)
Gene Name:
Htr2a
Organism: Mus musculus (Mouse)
Function: G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11960784, PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:21645528, PubMed:23129762, PubMed:23346101). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:18297054). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances (PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:23129762). Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (PubMed:11960784, PubMed:23346101)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cell projection, dendrite. Cell projection, axon. Cytoplasmic vesicle. Membrane, caveola. Presynapse
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