UniprotKB/SwissProt ID: P35283 (P35283)
Gene Name:
Rab12
Organism: Mus musculus (Mouse)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor (PubMed:21718402). Involved in autophagy (PubMed:23357852)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Recycling endosome membrane. Lysosome membrane. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome
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