Protein Name:
Ras-related protein Rab-21
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UniprotKB/SwissProt ID: P35282 (P35282)
Gene Name:
Rab21
Organism: Mus musculus (Mouse)
Function: Small GTPase involved in membrane trafficking control (PubMed:16754960, PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (PubMed:16754960). As a result, may regulate cell adhesion and migration (PubMed:16754960). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35282
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
27 |
SFKVVLLGEG C VGKTSLVLRY |
CCCCCCHHHH H CCCCCEEEEE |
2.95% |
21278135
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