Protein Name:
Tyrosine-protein phosphatase non-receptor type 11
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UniprotKB/SwissProt ID: P35235 (P35235)
Gene Name:
Ptpn11
Organism: Mus musculus (Mouse)
Function: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35235
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
104 |
DVIELKYPLN C ADPTSERWFH |
CCCCCCCCCC C CCCEEHHEEE |
6.31% |
21278135
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