Protein Name:
Catenin alpha-1
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UniprotKB/SwissProt ID: P35221 (P35221)
Gene Name:
CTNNA1
Organism: Homo sapiens (Human)
Function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (By similarity). May play a crucial role in cell differentiation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cell junction, adherens junction. Cell membrane. Cell junction. Cytoplasm. Nucleus. Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P35221
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
116 |
AAAGEFADDP C SSVKRGNMVR |
CCCEECCCCC C CCCCCCHHHH |
6.44% |
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| 2 |
228 |
VPILYTASQA C LQHPDVAAYK |
CCCEECCCCC C CCCCCCHHHH |
2.66% |
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| 3 |
324 |
SGAALMADSS C TRDDRRERIV |
CCCEECCCCC C CCCCCCHHHH |
4.13% |
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| 4 |
438 |
NKLIEVANLA C SISNNEEGVK |
CCCEECCCCC C CCCCCCHHHH |
4.12% |
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| 5 |
526 |
ENHILEDVNK C VIALQEKDVD |
CCCEECCCCC C CCCCCCHHHH |
1.95% |
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| 6 |
767 |
DKLGRTIADH C PDSACKQDLL |
CCCEECCCCC C CCCCCCHHHH |
4.05% |
2212679
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| 7 |
772 |
TIADHCPDSA C KQDLLAYLQR |
CCCEECCCCC C CCCCCCHHHH |
4.75% |
2212679
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