UniprotKB/SwissProt ID: P34974 (P34974)
Gene Name:
MC2R
Organism: Bos taurus (Bovine)
Function: Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function (By similarity). Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development (By similarity). Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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