Protein Name:
Bifunctional epoxide hydrolase 2
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UniprotKB/SwissProt ID: P34914 (P34914)
Gene Name:
Ephx2
Organism: Mus musculus (Mouse)
Function: Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:21217101, PubMed:7840649). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (By similarity) Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (By similarity). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P34914
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
IALKKKGFTT C IVTNNWLDDG |
CCCEEEEECC C CCCCCHHHHH |
1.82% |
21278135
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| 2 |
230 |
QFPEAPLPVP C NPNDVSHGYV |
CCCEEEEECC C CCCCCHHHHH |
15.65% |
22178444
21278135
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| 3 |
312 |
EIEEYAMELL C KEMVTFLDKL |
CCCEEEEECC C CCCCCHHHHH |
5.69% |
21278135
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| 4 |
521 |
PFLKRGHIED C GHWTQIEKPT |
CCCEEEEECC C CCCCCHHHHH |
2.53% |
21278135
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| 5 |
78 |
DESYRKSSKA C GANLPENFSI |
CCCEEEEECC C CCCCCHHHHH |
6.42% |
21278135
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