Protein Name:
Macrophage migration inhibitory factor
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UniprotKB/SwissProt ID: P34884 (P34884)
Gene Name:
Mif
Organism: Mus musculus (Mouse)
Function: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (By similarity). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Counteracts the anti-inflammatory activity of glucocorticoids (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:10933783, PubMed:16780921, PubMed:19188446). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:10933783, PubMed:16780921, PubMed:19188446)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P34884
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
81 |
AQNRNYSKLL C GLLSDRLHIS |
CCEEEEECCC C CCCCCCCHHH |
5.38% |
24926564
22588120
20925432
21278135
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