Protein Name:
DNA replication licensing factor MCM7
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UniprotKB/SwissProt ID: P33993 (P33993)
Gene Name:
MCM7
Organism: Homo sapiens (Human)
Function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for S-phase checkpoint activation upon UV-induced damage
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P33993
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
184 |
KPKMVVATYT C DQCGAETYQP |
CCHHHHHHHH H HHHHHHHHHH |
2.1% |
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| 2 |
378 |
GMKIRGNINI C LMGDPGVAKS |
CCHHHHHHHH H HHHHHHHHHH |
1.53% |
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| 3 |
442 |
GALVLADQGV C CIDEFDKMAE |
CCHHHHHHHH H HHHHHHHHHH |
1.84% |
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| 4 |
443 |
ALVLADQGVC C IDEFDKMAEA |
CCHHHHHHHH H HHHHHHHHHH |
4% |
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| 5 |
482 |
AGILTTLNAR C SILAAANPAY |
CCHHHHHHHH H HHHHHHHHHH |
2.49% |
24105792
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| 6 |
566 |
MKLMRRYIAM C REKQPMVPES |
CCHHHHHHHH H HHHHHHHHHH |
3.62% |
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| 7 |
67 |
EDDPELVDSI C ENARRYAKLF |
CCHHHHHHHH H HHHHHHHHHH |
3.7% |
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