Protein Name:
DNA replication licensing factor MCM5
|
UniprotKB/SwissProt ID: P33992 (P33992)
Gene Name:
MCM5
Organism: Homo sapiens (Human)
Function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P33992
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
207 |
CNTDQAGRPK C PLDPYFIMPD |
CCCCCCCCCC C CCCCCCCCCC |
4.48% |
|
| 2 |
221 |
PYFIMPDKCK C VDFQTLKLQE |
CCCCCCCCCC C CCCCCCCCCC |
5.07% |
|
| 3 |
249 |
GEMPRHMQLY C DRYLCDKVVP |
CCCCCCCCCC C CCCCCCCCCC |
3.06% |
|
| 4 |
355 |
GGTDMKKAIA C LLFGGSRKRL |
CCCCCCCCCC C CCCCCCCCCC |
2.51% |
|
| 5 |
397 |
KSQLLKFVEK C SPIGVYTSGK |
CCCCCCCCCC C CCCCCCCCCC |
3.56% |
|
| 6 |
443 |
AMVLADGGVV C IDEFDKMRED |
CCCCCCCCCC C CCCCCCCCCC |
2.78% |
|
| 7 |
482 |
AGITTTLNSR C SVLAAANSVF |
CCCCCCCCCC C CCCCCCCCCC |
3.11% |
19483679
|
| 8 |
566 |
LAKLKKFIAY C RVKCGPRLSA |
CCCCCCCCCC C CCCCCCCCCC |
2.74% |
|
|
