UniprotKB/SwissProt ID: P33896 (P33896)
Gene Name:
Ifnar1
Organism: Mus musculus (Mouse)
Function: Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:14532120, PubMed:1533935, PubMed:24075985). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (PubMed:23872679)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Late endosome. Lysosome
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