Protein Name:
Cadherin-related tumor suppressor
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UniprotKB/SwissProt ID: P33450 (P33450)
Gene Name:
ft
Organism: Drosophila melanogaster (Fruit fly)
Function: Involved in regulation of planar cell polarity in the compound eye where it is required for correct specification of the R3 and R4 photoreceptor cells by regulating Fz activity in the R3/R4 precursor cells (PubMed:11893338). This is likely to occur through creation of an ft gradient so that the equatorial R3/R4 precursor cell has a higher level of ft function than its polar neighbor (PubMed:15548581). Also required for planar cell polarity of wing hairs (PubMed:12540853, PubMed:15240556). Mediates heterophilic cell adhesion in vitro and is required to stabilize ds on the cell surface (PubMed:15240556). Involved in regulation of eye imaginal disk size (PubMed:23667559). Upstream component of the Hippo pathway where it is likely to act as a cell surface receptor involved in regulation of tissue size and is required for the localization and stability of ex (PubMed:16996265). Probably acts as a cell surface receptor for ds (PubMed:20434335) Regulates mitochondrial electron transport chain integrity and promotes oxidative phosphorylation
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Apical cell membrane. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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