Protein Name:
Kinesin-1 heavy chain
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UniprotKB/SwissProt ID: P33176 (P33176)
Gene Name:
KIF5B
Organism: Homo sapiens (Human)
Function: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytolytic granule membrane. Lysosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P33176
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
174 |
YVKGCTERFV C SPDEVMDTID |
CCCHHHCCEE E EEEECCCCHH |
4.49% |
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| 2 |
294 |
RILQDSLGGN C RTTIVICCSP |
CCCHHHCCEE E EEEECCCCHH |
4.65% |
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| 3 |
330 |
QRAKTIKNTV C VNVELTAEQW |
CCCHHHCCEE E EEEECCCCHH |
1.41% |
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| 4 |
421 |
GNFTDAERRK C EEEIAKLYKQ |
CCCHHHCCEE E EEEECCCCHH |
8.25% |
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| 5 |
632 |
MEENEKELAA C QLRISQHEAK |
CCCHHHCCEE E EEEECCCCHH |
3.05% |
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| 6 |
65 |
STSQEQVYND C AKKIVKDVLE |
CCCHHHCCEE E EEEECCCCHH |
5.49% |
2212679
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| 7 |
7 |
----MADLAE C NIKVMCRFRP |
CCCHHHCCEE E EEEECCCCHH |
5.47% |
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| 8 |
858 |
QLVRDNADLR C ELPKLEKRLR |
CCCHHHCCEE E EEEECCCCHH |
9.06% |
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