Protein Name:
Pyrroline-5-carboxylate reductase 1, mitochondrial
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UniprotKB/SwissProt ID: P32322 (P32322)
Gene Name:
PYCR1
Organism: Homo sapiens (Human)
Function: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H (PubMed:16730026, PubMed:19648921, PubMed:23024808, PubMed:28258219). At physiologic concentrations, has higher specific activity in the presence of NADH (PubMed:16730026, PubMed:23024808). Involved in the cellular response to oxidative stress (PubMed:16730026, PubMed:19648921)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P32322
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
AFRPAPRVIR C MTNTPVVVRE |
CCCCCCCHHH H HHHHHHCCCH |
2.44% |
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| 2 |
262 |
SLLINAVEAS C IRTRELQSMA |
CCCCCCCHHH H HHHHHHCCCH |
2.92% |
19483679
37478858
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| 3 |
95 |
DIEDRHIVVS C AAGVTISSIE |
CCCCCCCHHH H HHHHHHCCCH |
1.71% |
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