Protein Name:
Sterol carrier protein 2
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UniprotKB/SwissProt ID: P32020 (P32020)
Gene Name:
Scp2
Organism: Mus musculus (Mouse)
Function: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids (PubMed:10706581). Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA) (PubMed:10706581). Also active with medium and long straight chain 3-oxoacyl-CoAs (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048) Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis (By similarity). Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA (PubMed:9553048). Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides (PubMed:11003606). Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3 (PubMed:11003606). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (PubMed:9553048)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Peroxisome. Endoplasmic reticulum. Mitochondrion. Peroxisome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P32020
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
495 |
VLPNSDKKAD C TITMADSDLL |
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22178444
20925432
21278135
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