Protein Name:
14-3-3 protein beta/alpha
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UniprotKB/SwissProt ID: P31946 (P31946)
Gene Name:
YWHAB
Organism: Homo sapiens (Human)
Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Melanosome. Vacuole membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P31946
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
191 |
YEILNSPEKA C SLAKTAFDEA |
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| 2 |
96 |
EKIEAELQDI C NDVLELLDKY |
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