Protein Name:
Bifunctional purine biosynthesis protein ATIC
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UniprotKB/SwissProt ID: P31939 (P31939)
Gene Name:
ATIC
Organism: Homo sapiens (Human)
Function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:10985775, PubMed:11948179, PubMed:9378707). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P31939
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
101 |
LDFNLIRVVA C NLYPFVKTVA |
CCCCCEEEEE E CCCCCHHHHH |
2.14% |
37478858
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| 2 |
146 |
AKNHARVTVV C EPEDYVVVST |
CCCCCEEEEE E CCCCCHHHHH |
6.67% |
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| 3 |
241 |
LNGAPGFINL C DALNAWQLVK |
CCCCCEEEEE E CCCCCHHHHH |
2.19% |
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| 4 |
287 |
IPLSEDEAKV C MVYDLYKTLT |
CCCCCEEEEE E CCCCCHHHHH |
1.18% |
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| 5 |
325 |
FGDFVALSDV C DVPTAKIISR |
CCCCCEEEEE E CCCCCHHHHH |
5.39% |
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| 6 |
363 |
ILSKKKNGNY C VLQMDQSYKP |
CCCCCEEEEE E CCCCCHHHHH |
2.6% |
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| 7 |
434 |
AVKYTQSNSV C YAKNGQVIGI |
CCCCCEEEEE E CCCCCHHHHH |
2.47% |
19483679
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