Protein Name:
DnaJ homolog subfamily A member 1
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UniprotKB/SwissProt ID: P31689 (P31689)
Gene Name:
DNAJA1
Organism: Homo sapiens (Human)
Function: Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as a co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Cytoplasm. Microsome. Nucleus. Cytoplasm, perinuclear region. Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P31689
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
134 |
RKLALQKNVI C DKCEGRGGKK |
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| 2 |
153 |
KKGAVECCPN C RGTGMQIRIH |
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| 3 |
302 |
GQIVKHGDIK C VLNEGMPIYR |
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