UniprotKB/SwissProt ID: P31648 (P31648)
Gene Name:
Slc6a1
Organism: Mus musculus (Mouse)
Function: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:30270321, PubMed:8420981). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Presynapse
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